SerImmune’s ImmuneIT platform maps circulating antibodies to their diverse antigens using molecular libraries composed of billions of antigen decoys and big data informatic tools.
The structure of each antibody of an immune repertoire encodes a unique antigen epitope fingerprint. To determine the antigen epitopes associated with many antibodies in parallel, SerImmune probes the repertoire within a specimen with a diverse peptide library capable of representing many antigens. Library members binding to antibodies in the repertoire are separated and their peptide sequences are determined using massively parallel DNA sequencing. Antigen epitopes specific to a sample, cohort, disease or phenotype are then discovered using statistical search algorithms and cloud computing.
Through application of our platform to well characterized specimens, SerImmune has constructed a database of disease- and health-associated antigen epitopes. Using this database, specimens can be analyzed for the presence of antibodies targeting many distinct antigen epitopes in parallel, to deeply characterize immune repertoires.
SerImmune’s ImmuneIT platform provides the capability to determine the composition of functional immune repertoires, creating new opportunities for therapeutic and diagnostic development.